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KMID : 0043319990220030302
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Archives of Pharmacal Research
1999 Volume.22 No. 3 p.302 ~ p.305
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Synthesis of 4-Hydroxy-1-thiocounmarin Derivatives-1 : An Efficient Synthesis of Thioflocoumafen
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Jung Jae-Chul
Kim Ju-Cheun
Park Oee-Sook
Jang Bong-Suek
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Abstract
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An efficient procedure for the preparation of 4-hydroxy-3-{1,2,3,4-tetra-hydro-3-[4-(4-trifluoromethylbenzyloxy)phenyl]-1-naphthyl}thiocoumarin (thioflocoumafen, 1a and 1b) is described. The key step in the synthesis involves the condensation reaction of 3-(4-methoxyphenyl)-1-tetralol (2) with 4-hydroxy-1-thiocoumarin (3).
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KEYWORD
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Thioflocoumafen, 4-Hydroxy-1-thicoumarin, Anticogaulant, Rodenticide
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